Year of great discovery/work
Beginning in 1970, Provost worked under Maurice Hilleman at Merck. His efforts focused on hepatitis A. By figuring out how to grow large quantities of hepatitis A in cell culture, he was able to pave the way for development of a hepatitis A vaccine. After hepatitis A vaccine was licensed in 1995, national infection rates declined by 75 percent.
Provost first showed that marmosets and tamarins were good animal models to study hepatitis A infections.